There are currently 48 active clinical trials seeking participants for Autism research studies. The states with the highest number of trials for Autism participants are California, Florida, Ohio and New York.
Improving Academic and Social Functioning in Middle-Schoolers With Autism
NCT06705907
Recruiting
The goal of this study is to test how well two group interventions work for middle-school children with Autism Spectrum Disorder (ASD). One of the interventions focuses on teaching parents and adolescent skills to help improve their social functioning and the other focuses on teaching parents and adolescents skills to improve organization, planning, and study skills. Eligible participants will be randomly (like a coin flip) assigned to attend one of the two interventions.
Gender:
ALL
Ages:
Between 10 years and 15 years
Trial Updated:
02/03/2025
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Autism, Autism Spectrum Disorder
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Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
NCT06670040
Recruiting
Evaluate the efficacy of accelerated theta burst stimulation (aTBS) in reducing depressive symptoms in autism spectrum disorder (ASD)
Gender:
ALL
Ages:
Between 13 years and 26 years
Trial Updated:
10/31/2024
Locations: Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio
Conditions: ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder, MDD
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Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
NCT06362733
Recruiting
The purpose of this open label trial is to examine the preliminary feasibility, acceptability, and effectiveness of a 12-week behavioral intervention program (1 hour/week) to treat insistence on sameness (e.g., difficulty tolerating changes in routine) in youth with autism spectrum disorder (ASD). Treatment will be delivered via secure telemedicine platform and consist of a combination of parent-training and parent-mediated intervention with the child.
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
08/19/2025
Locations: 401 Quarry Road (Remote Study), Stanford, California
Conditions: Autism Spectrum Disorder, Restricted Behavior, Autism
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Trial of Diphenhydramine for Sleep in Children With Autism
NCT05501678
Recruiting
The purpose of this study is to examine the effect of diphenhydramine on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Diphenhydramine is an anti-histaminergic agent with strong hypnotic properties. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of diphenhydramine on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Register for Updates
Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
NCT04532424
Recruiting
Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism Spectrum Disorder, Autism, Asperger Syndrome
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Trial of Zolpidem for Sleep in Children With Autism
NCT05540574
Recruiting
The purpose of this study is to examine the effect of zolpidem on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Zolpidem is a nonbenzodiazepine GABAa receptor agonist drug that acts as a hypnotic. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of zolpidem on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Register for Updates
Trial of Suvorexant for Sleep in Children With Autism
NCT05546554
Recruiting
The purpose of this study is to examine the effect of suvorexant on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Suvorexant is a selective, dual orexin receptor antagonist (DORA) used for the treatment of sleep onset difficulties and/or sleep maintenance. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of suvorexant on sleep physiology as assessed by polysomnography (PSG), ac... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Register for Updates
The Neurodevelopmental and Behavioral Phenotyping Screening Protocol
NCT00271622
Recruiting
The purpose of this protocol is to allow for the careful evaluation of healthy volunteers and individuals with risk for psychiatric disorders or neurodevelopmental disorders, such as autism spectrum disorder for specific protocols at NIH....
Gender:
ALL
Ages:
6 weeks and above
Trial Updated:
08/09/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Neurologic Disorders, Autism, Neurodegenerative Disease, Neurobehavioral Manifestation
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The Power Down Pilot Study: A Novel Bedtime Manipulation Protocol
NCT06386029
Recruiting
The goal of this pilot intervention study is to examine the feasibility and acceptability of a novel bedtime manipulation protocol called "The Power Down" for autistic youth, ages 6-10. The main questions it aims to answer are: 1. Is the Power Down feasible for caregivers to do each night? 2. Do the families find the Power Down an acceptable intervention to address their child's difficulties settling down to fall asleep?
Gender:
ALL
Ages:
Between 6 years and 10 years
Trial Updated:
08/08/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Autism, Sleep Disturbance
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Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety
NCT06537128
Recruiting
Anxiety is very common in autistic youth. Cognitive behavioral therapy (CBT) is the recommended treatment for both autistic and typically-developing (TD) youth with anxiety, yet most families cannot access CBT due to cost, practicalities of attending in-person treatment sessions, and a shortage of trained providers, especially in rural areas. The goal of this project is to increase access to care for families of autistic adolescents with anxiety through an internet-based treatment model.
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
07/18/2025
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Autism Spectrum Disorder, Autism, Anxiety, Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder
Register for Updates
Telehealth Parent-Implemented Intervention for Young Children With Autism Spectrum Disorder (ASD)
NCT05176808
Recruiting
The primary objective of this research study is to improve outcomes involving core social-communication symptoms for young children with ASD or social communication delays by increasing access to clinically validated early behavioral intervention through a telehealth parent coaching model. The investigators will test the hypothesis that telehealth-delivered Naturalistic Developmental Behavioral Intervention parent coaching (TC) is non-inferior to in-person coaching (IPC) for the treatment of cor... Read More
Gender:
ALL
Ages:
Between 18 months and 42 months
Trial Updated:
07/10/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Autism Spectrum Disorder, Autistic Disorder, Active Autistic Disorder, Autism, Asperger Syndrome, PDD-NOS, Social Communication Delay, Mixed Expressive Receptive Language Disorder, Other Symbolic Dysfunctions
Register for Updates
SenseToKnow Autism Screening Device Validation Study
NCT05874466
Recruiting
This is a pivotal, prospective, double-blind, study to evaluate the sensitivity and specificity of the SenseToKnow app for the detection of autism spectrum disorder in children 16-36 months of age.
Gender:
ALL
Ages:
Between 16 months and 36 months
Trial Updated:
05/23/2025
Locations: Duke University, Durham, North Carolina
Conditions: Autism, Autism Spectrum Disorder
Register for Updates